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Transcranial focused ultrasound stimulation (tFUS) has emerged as a potential noninvasive therapeutic technology. Due to skull attenuations at high ultrasound (US) frequencies, successful tFUS with sufficient penetration depth requires sub-MHz US waves, leading to relatively poor stimulation specificity particularly in the axial direction (perpendicular to the US transducer). This shortcoming can potentially be overcome by utilizing two individual US beams properly crossed in time and space. For large-scale tFUS, a phased array is also required to dynamically steer focused US beams at desired neural targets. This article presents the theoretical foundation and optimization (through a wave-propagation simulator) of crossed-beam formation using two US phased arrays.more » « less
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